| First Author | Xie C | Year | 2008 |
| Journal | Int Immunol | Volume | 20 |
| Issue | 6 | Pages | 719-28 |
| PubMed ID | 18381352 | Mgi Jnum | J:136171 |
| Mgi Id | MGI:3795343 | Doi | 10.1093/intimm/dxn030 |
| Citation | Xie C, et al. (2008) Strain distribution pattern of immune nephritis--a follow-up study. Int Immunol 20(6):719-28 |
| abstractText | Previous studies have indicated that the NZW, DBA/1, 129/sv and BUB strains are particularly sensitive to experimental anti-glomerular basement membrane (GBM)-induced immune nephritis. The present study extends previous observations by examining eight additional inbred mouse strains for their susceptibility to immune nephritis. Unlike the ALR/Lt, CAST/Ei, DDY/JclSidSeyFrk, FVB/NJ, PERA/Ei, SB/Le and BALB/c strains, the C58 mouse strain was observed to be particularly susceptible to experimental immune nephritis, with CBA mice being a close second. In contrast to the other strains, C58 mice uniformly developed heavy proteinuria, azotemia and severe glomerulonephritis with prominent crescent formation and tubulointerstitial nephritis following challenge with anti-GBM sera. These differences were associated with increased murine Ig deposition, leukocyte infiltration and IFN-gamma production within the kidneys of C58 mice. Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted. |
