| First Author | Yao PJ | Year | 2005 |
| Journal | Biochem Biophys Res Commun | Volume | 330 |
| Issue | 1 | Pages | 34-8 |
| PubMed ID | 15781228 | Mgi Jnum | J:97468 |
| Mgi Id | MGI:3575485 | Doi | 10.1016/j.bbrc.2005.02.121 |
| Citation | Yao PJ, et al. (2005) Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer's disease model. Biochem Biophys Res Commun 330(1):34-8 |
| abstractText | A recently described triple-transgenic mouse model (3xTg, PS1(M146V), APP(Swe), and tau(P301L)) develops a neuropathology similar to the brains of Alzheimer's disease patients including progressive deposits of plaques and tangles [Neuron 39 (2003) 409]. These mice also show age-related deficits in hippocampal synaptic plasticity that occurs before the development of plaques and tangles. Here we report unchanged synaptic vesicle recycling, as measured by FM1-43 release, in the hippocampal neurons of the 3xTg mice. Expression levels of presynaptic protein synaptophysin and of proteins involved in synaptic vesicle recycling including AP180, dynamin I, and synaptotagmin I also remain unaffected. These data suggest that the synaptic deficits observed in the 3xTg neurons may not arise from the preserved synaptic vesicle recycling. |
