| First Author | Zou SS | Year | 2013 |
| Journal | Cancer Lett | Volume | 335 |
| Issue | 1 | Pages | 160-7 |
| PubMed ID | 23410872 | Mgi Jnum | J:198312 |
| Mgi Id | MGI:5496329 | Doi | 10.1016/j.canlet.2013.02.008 |
| Citation | Zou SS, et al. (2013) Role of beta-Catenin in regulating the balance between TNF-alpha- and Fas-induced acute liver injury. Cancer Lett 335(1):160-7 |
| abstractText | beta-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of beta-Catenin in acute liver failure remains unclear. Using hepatocyte specific beta-Catenin knockout mice, we found that loss of beta-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of beta-Catenin attributes on its function of inhibiting NF-kappaB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, beta-Catenin plays an important role in regulating the balance between TNF-alpha and Fas-induced liver injury via its effect on NF-kappaB. |
