| First Author | Yin C | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 30 | Pages | 4137-42 |
| PubMed ID | 19041309 | Mgi Jnum | J:142702 |
| Mgi Id | MGI:3821970 | Doi | 10.1016/j.febslet.2008.11.014 |
| Citation | Yin C, et al. (2008) Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice. FEBS Lett 582(30):4137-42 |
| abstractText | We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat-shock (HS) showed a significant increase of miRNA-1, miRNA-21 and miRNA-24 in the heart. miRNAs isolated from HS mice and injected into non-HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro-apoptotic genes and increase in anti-apoptotic genes. Chemically synthesized miRNA-21 also reduced infarct size, whereas a miRNA-21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA's in cardioprotection following I/R injury. |
