| First Author | Gibson DM | Year | 1984 |
| Journal | Immunogenetics | Volume | 20 |
| Issue | 5 | Pages | 493-501 |
| PubMed ID | 6437974 | Mgi Jnum | J:7648 |
| Mgi Id | MGI:56117 | Doi | 10.1007/BF00364352 |
| Citation | Gibson DM, et al. (1984) Recombination between kappa chain genetic markers in the mouse. Immunogenetics 20(5):493-501 |
| abstractText | In this study we report the first instance of recombination between kappa chain genetic markers in the mouse. The recombination frequency, 0.45% (95% limits, 0.12-1.61), is similar to that previously found for recombination between the kappa chain locus and the Lyt-2,3 locus (0.3%, 95% limits, 0.05-1.6), but is relatively low in comparison with that found at the heavy chain locus (0.41-5.4%). Lyt-2,3-typing of the recombinants permits a partial ordering of the kappa chain and Lyt-2,3 loci as (Lyt-2,3, Igk-Ef1) - Igk-Ef2. Light chains controlled by the two kappa markers include the Vk-(ser) subgroup (controlled by Igk-Ef1) and Vk-1 (controlled by Igk-Ef2). One of the recombinants has been recovered in a homozygous state (NAK) and should be suitable for Vk gene mapping studies. |
