| First Author | Stefkovich ML | Year | 2018 |
| Journal | Steroids | Volume | 133 |
| Pages | 34-37 | PubMed ID | 29122548 |
| Mgi Jnum | J:263739 | Mgi Id | MGI:6192846 |
| Doi | 10.1016/j.steroids.2017.11.001 | Citation | Stefkovich ML, et al. (2018) Experimental models for evaluating non-genomic estrogen signaling. Steroids 133:34-37 |
| abstractText | Non-genomic effects of estrogen receptor alpha (ERalpha) signaling have been described for decades. However, the mechanisms and physiological processes resulting solely from non-genomic signaling are poorly understood. Challenges in studying these effects arise from the strongly nucleophilic tendencies of estrogen receptor, and many approaches to excluding ERalpha from the nucleus have been explored over the years. In this review, we discuss past strategies for studying ERalpha's non-genomic action and current models, specifically H2NES ERalpha, first described by Burns et al. (2011). In vitro and preliminary in vivo data from H2NES ERalpha and H2NES mice suggest a promising avenue for pinpointing specific non-genomic ERalpha action. |
