| First Author | Li Y | Year | 2018 |
| Journal | J Immunol | Volume | 201 |
| Issue | 9 | Pages | 2612-2623 |
| PubMed ID | 30266770 | Mgi Jnum | J:267979 |
| Mgi Id | MGI:6258183 | Doi | 10.4049/jimmunol.1700808 |
| Citation | Li Y, et al. (2018) STAT6 and Furin Are Successive Triggers for the Production of TGF-beta by T Cells. J Immunol 201(9):2612-2623 |
| abstractText | Production of TGF-beta by T cells is key to various aspects of immune homeostasis, with defects in this process causing or aggravating immune-mediated disorders. The molecular mechanisms that lead to TGF-beta generation by T cells remain largely unknown. To address this issue, we take advantage of the fact that intestinal helminths stimulate Th2 cells besides triggering TGF-beta generation by T lymphocytes and regulate immune-mediated disorders. We show that the Th2 cell-inducing transcription factor STAT6 is necessary and sufficient for the expression of TGF-beta propeptide in T cells. STAT6 is also necessary for several helminth-triggered events in mice, such as TGF-beta-dependent suppression of alloreactive inflammation in graft-versus-host disease. Besides STAT6, helminth-induced secretion of active TGF-beta requires cleavage of propeptide by the endopeptidase furin. Thus, for the immune regulatory pathway necessary for TGF-beta production by T cells, our results support a two-step model, composed of STAT6 and furin. |
