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Publication : Retinoic acid induction of mouse cellular retinoic acid-binding protein-I gene expression is enhanced by sphinganine.

First Author  Wei LN Year  1995
Journal  Mol Cell Endocrinol Volume  111
Issue  2 Pages  207-11
PubMed ID  7556883 Mgi Jnum  J:27452
Mgi Id  MGI:74932 Doi  10.1016/0303-7207(95)03570-w
Citation  Wei LN, et al. (1995) Retinoic acid induction of mouse cellular retinoic acid-binding protein-I gene expression is enhanced by sphinganine. Mol Cell Endocrinol 111(2):207-11
abstractText  Cellular retinoic acid-binding protein-I (CRABP-I) gene expression is induced in mouse embryonal carcinoma P19 cells specifically by retinoic acid (RA) and the induction is enhanced by sphinganine. The effects of retinoic acid and sphinganine on CRABP-I gene expression can be accounted for by a stimulation of its transcription rate. Using a lacZ reporter system, it was determined that a DNA fragment containing a putative AP-1 binding site in the promoter region of CRABP-I gene is required for the up-regulation of CRABP-I gene transcription.
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