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Publication : The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

First Author  Hanks SK Year  1988
Journal  Science Volume  241
Issue  4861 Pages  42-52
PubMed ID  3291115 Mgi Jnum  J:31015
Mgi Id  MGI:78324 Doi  10.1126/science.3291115
Citation  Hanks SK, et al. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241(4861):42-52
abstractText  In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino acid sequences deduced from the nucleotide sequences of molecularly cloned genes or complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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