Primary Identifier | IPR004577 | Type | Family |
Short Name | Ogg1 |
description | One of the major base lesions induced by oxidative stress is 8-oxoguanine (8-oxoG), one of the oxidised forms of guanine. 8-oxoguanine DNA glycosylase (also known as N-glycosylase/DNA lyase) functions in base excision repair and is responsible for the excision of 8-oxoguanine. It has beta-lyase activity thatnicks DNA 3' to the lesion [, , ]. |