| Primary Identifier | IPR028334 | Type | Family |
| Short Name | GPR55 |
| description | Several 7TM receptors have been cloned but theirendogenous ligands are unknown; these have been termed orphan receptors. However, recent research has identified certain pharmacological targets that could be investigated to find, for example, new potential cannabinoid receptors or channels [, , ]. GPR18 [, ], GPR55 [, ], GPR119 []show little structural similarity to CB1 and CB2 receptors, but they respond to endogenous agents analogous to the endogenous cannabinoid ligands, as well as some natural/synthetic cannabinoid receptor ligands []. However, because they do not fulfill all of the cannabinoid receptor criteria defined by IUPHAR, the classification of these proteins remains a contentious issue due to conflicting pharmacological results. As a result, they remain classified as putative endogenous agonists by IUPHAR [].This entry represents G protein-coupled receptor 55. It is thought to play a role in bone physiology by regulating osteoclast number and function []. |
