| First Author | Gupta SS | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 7 | Pages | 1862-1877.e7 |
| PubMed ID | 31722203 | Mgi Jnum | J:293104 |
| Mgi Id | MGI:6445355 | Doi | 10.1016/j.celrep.2019.10.032 |
| Citation | Gupta SS, et al. (2019) NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells. Cell Rep 29(7):1862-1877.e7 |
| abstractText | Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8(+) T cells remain unclear. Here we show that deficiency in NIX-dependent mitophagy leads to metabolic defects in effector memory T cells. Deletion of NIX caused HIF1alpha accumulation and altered cellular metabolism from long-chain fatty acid to short/branched-chain fatty acid oxidation, thereby compromising ATP synthesis during effector memory formation. Preventing HIF1alpha accumulation restored long-chain fatty acid metabolism and effector memory formation in antigen-specific CD8(+) T cells. Our study suggests that NIX-mediated mitophagy is critical for effector memory formation in T cells. |
