| First Author | MacMillan LB | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5276 | Pages | 801-3 |
| PubMed ID | 8670421 | Mgi Jnum | J:34820 |
| Mgi Id | MGI:82286 | Doi | 10.1126/science.273.5276.801 |
| Citation | MacMillan LB, et al. (1996) Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science 273(5276):801-3 |
| abstractText | alpha2-Adrenergic receptors (alpha2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three alpha2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of alpha2AR agonists with imidazoline receptors has precluded an understanding of the role of individual alpha2AR subtypes in the hypotensive response. Gene targeting was used to introduce a point mutation into the alpha2aAR subtype in the mouse genome. The hypotensive response to alpha2AR agonists was lost in the mutant mice, demonstrating that the alpha2aAR subtype plays a principal role in this response. |
