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Protein Coding Gene : Mettl4 methyltransferase 4, N6-adenosine
Primary Identifier  MGI:1924031 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  76781
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in mitochondrial matrix. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit sublethality, craniofacial dysmorphism, anemia, decreased leukocyte cell number, enlarged spleen, anophthalmia, and reduced fertility. [provided by MGI curators]
  • synonyms:
  • expressed sequence AV296509,
  • MGI:2442064,
  • 2410198H06Rik,
  • RIKEN cDNA A730091E08 gene,
  • AV296509,
  • Mettl4,
  • A730091E08Rik,
  • MGI:3035147,
  • HsT661,
  • RIKEN cDNA 2410198H06 gene,
  • methyltransferase 4, N6-adenosine
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