Primary Identifier | MGI:1333883 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 16798 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and nuclear estrogen receptor binding activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in spindle pole. Is expressed in several structures, including central nervous system; early conceptus; lung; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). PHENOTYPE: Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors. [provided by MGI curators] |