| First Author | Lee S | Year | 2020 |
| Journal | iScience | Volume | 23 |
| Issue | 5 | Pages | 101106 |
| PubMed ID | 32434140 | Mgi Jnum | J:338654 |
| Mgi Id | MGI:6717805 | Doi | 10.1016/j.isci.2020.101106 |
| Citation | Lee S, et al. (2020) RORgammat-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23(5):101106 |
| abstractText | Epigenetic regulation, including chromatin accessibility and posttranslational modifications of histones, is of importance for T cell lineage decision. TH17 cells play a critical role in protective mucosal immunity and pathogenic multiple autoimmune diseases. The differentiation of TH17 cells is dictated by a master transcription factor, RORgammat. However, the epigenetic mechanism that controls TH17 cell differentiation remains poorly understood. Here we show that the Swi/Snf complex is required for TH17-mediated cytokine production both in vitro and in vivo. We demonstrate that RORgammat recruits and forms a complex with the Swi/Snf complex to cooperate for the RORgammat-mediated epigenetic modifications of target genes, including both permissive and repressive ones for TH17 cell differentiation. Our findings thus highlight the Swi/Snf complex as an essential epigenetic regulator of TH17 cell differentiation and provide a basis for the understanding of how a master transcription factor RORgammat collaborates with the Swi/Snf complex to govern epigenetic regulation. |
