| First Author | Edwards SK | Year | 2014 |
| Journal | Leuk Res | Volume | 38 |
| Issue | 3 | Pages | 393-401 |
| PubMed ID | 24418753 | Mgi Jnum | J:245012 |
| Mgi Id | MGI:5913791 | Doi | 10.1016/j.leukres.2013.12.016 |
| Citation | Edwards SK, et al. (2014) Expression and function of a novel isoform of Sox5 in malignant B cells. Leuk Res 38(3):393-401 |
| abstractText | Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3(-/-) B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3(-/-) B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and beta-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells. |
