| First Author | She ZY | Year | 2020 |
| Journal | Biochim Biophys Acta Mol Cell Res | Volume | 1867 |
| Issue | 4 | Pages | 118636 |
| PubMed ID | 31884069 | Mgi Jnum | J:287870 |
| Mgi Id | MGI:6390245 | Doi | 10.1016/j.bbamcr.2019.118636 |
| Citation | She ZY, et al. (2020) Kinesin-6 family motor KIF20A regulates central spindle assembly and acrosome biogenesis in mouse spermatogenesis. Biochim Biophys Acta Mol Cell Res 1867(4):118636 |
| abstractText | Kinesin-6 KIF20A is essential for microtubule organization and central spindle assembly during cytokinesis. However, the functions of KIF20A in meiotic division and spermatogenesis remain elusive. Here, we report that kinesin-6 KIF20A locates at the microtubules in mouse spermatogenic cells and co-localizes with the spindle midzone and midbody. We demonstrate that central spindle organization and chromosomal stability are regulated by KIF20A in male meiotic division. KIF20A inhibition leads to the defects in central spindle assembly and cytokinetic abscission, and finally results in the increase of aneuploid cells and the alteration of cell populations in the spermatogenic cells. Furthermore, we have revealed that kinesin-6 KIF20A is associated with the formation and maturation of the acrosomes during spermatogenesis. Our findings have identified the specific roles of KIF20A in central spindle organization in meiotic division. |
