| First Author | Chan VW | Year | 1998 |
| Journal | J Exp Med | Volume | 188 |
| Issue | 1 | Pages | 93-101 |
| PubMed ID | 9653087 | Mgi Jnum | J:115145 |
| Mgi Id | MGI:3690715 | Doi | 10.1084/jem.188.1.93 |
| Citation | Chan VW, et al. (1998) The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med 188(1):93-101 |
| abstractText | The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C beta I/II (PKCbetaI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation. |
