|  Help  |  About  |  Contact Us

Allele : Sv2a<tm1.4Ygua> synaptic vesicle glycoprotein 2a; targeted mutation 1.4, Yihui Guan

Primary Identifier  MGI:7574709 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Sv2a
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site was inserted upstream of exon 3 and a neomycin resistance gene flanked by self-deletion anchor sites, a lox2272 site, a SA-2A-dTomato-polyA cassette in reverse orientation, a second loxP and lox2272 sites were inserted downstream of exon 3 in intron 3. The neomycin resistance gene was self-excised. Cre-mediated recombination either inverted the dTomato cassette and exon 3 using the loxP sites, such that the dTomato cassette is now upstream of exon 3 or inverted just the dTomato cassette using lox2272. Cre-mediated excionsion using loxP deleted exon 3.
  • mutations:
  • Insertion,
  • Intragenic deletion
Quick Links:
 
Quick Links:
 

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele