| Primary Identifier | MGI:7526734 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence, Null/knockout | Gene | Kras |
| Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6NCrl)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An FRT site flanked neomycin resistance gene and STOP cassette was inserted into intron 1. Exon 2, the first coding exon, was modified by changing glycine codon 12 (GGT) to cysteine (TGT) (p.G12C). The allele will only be expressed after Flp-mediated removal of the neo-STOP cassette. The mutation is the equivalent of the same human mutation found in lung adenocarcinoma. |
