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Allele : Trp53<tm3.1Glo> transformation related protein 53; targeted mutation 3.1, Guillermina Lozano
Primary Identifier  MGI:3528279 Allele Type  Targeted
Attribute String  Dominant negative, Humanized sequence Gene  Trp53
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Arginine codon 172 (CGC) was changed to histidine (CAC) (c.515G>A, p.R172H, equivalent to p.R175H in humans) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was excised via Cre-mediated recombination. Western blot analysis of homozygous MEFs detected mutant protein.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • p53<R172H>,
  • p53<515A>,
  • p53<H>,
  • p53<515A>,
  • p53<R172H>,
  • p53<H>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

4 Carried By

Trail: Allele

0 Driven By

38 Publication categories

Trail: Allele




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