| First Author | Bradbury JM | Year | 1995 |
| Journal | Dev Biol | Volume | 170 |
| Issue | 2 | Pages | 553-63 |
| PubMed ID | 7649383 | Mgi Jnum | J:28313 |
| Mgi Id | MGI:75934 | Doi | 10.1006/dbio.1995.1236 |
| Citation | Bradbury JM, et al. (1995) Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev Biol 170(2):553-63 |
| abstractText | Expression of Wnt-4, a member of the Wnt gene family, is induced during early pregnancy in the mouse mammary gland. To investigate the function of Wnt-4, we used a recombinant retrovirus to constitutively express the gene in transplanted mammary epithelium grown in virgin animals. In fully grown glands, Wnt-4 expression resulted in ducts that were more highly branched than normal and caused some premature alveolar development. These changes resembled those seen during pregnancy, suggesting that endogenous Wnt-4 expression may regulate epithelial branching in early pregnancy. The modified growth pattern induced by Wnt-4 expression was similar to that induced by Wnt-1, one of the members of the Wnt gene family activated by mouse mammary tumour virus. As Wnt-1 is not normally expressed in the mammary gland, it may exert its effect on the mammary gland by activating a developmental pathway normally regulated by Wnt-4. |
