| Primary Identifier | IPR005681 | Type | Family |
| Short Name | Tim23 |
| description | The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor"proteins. The inner membrane translocase is formed of a complex with a number of proteins, including the Tim17, Tim23 and Tim44 subunits. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane [].The TIM23 complex forms a dynamic multisubunit machinery that recognises preproteins and can transport them into the inner membrane or into the matrix. It is composed of three subunits, Tim50, Tim23, and Tim17, that expose the domains to the intermembrane space. This entry includes the mitochondrial import inner membrane translocase subunit Tim23, consisting of an N-terminal intermembrane space domain that interacts with Tim50, and a C-terminal membrane-embeddeddomain that, together with Tim17, forms a protein-conducting channel across the inner membrane. Tim50 helps keeping the Tim23 channel in a closed state in the absence of presequence proteins, regulating the gating through the TIM channel [, ]. |
