First Author | Li C | Year | 2012 |
Journal | Cell Immunol | Volume | 279 |
Issue | 2 | Pages | 151-9 |
PubMed ID | 23246676 | Mgi Jnum | J:192534 |
Mgi Id | MGI:5465350 | Doi | 10.1016/j.cellimm.2012.09.012 |
Citation | Li C, et al. (2012) Protective function of an unconventional gammadelta T cell subset against malaria infection in apoptosis inhibitor deficient mice. Cell Immunol 279(2):151-9 |
abstractText | Various subsets of T-cell receptor (TCR) gammadelta(+) T cells expressing distinct TCR-Vgamma chains are found in many different anatomical locations. These TCR gammadelta(+) T cells perform multiple functions as an essential part of the immune system. In particular, protection against malaria infection by TCR gammadelta(+) T cells is of special interest. In the present study, we confirmed that the Vgamma7(+) gammadelta T cells, which are an unconventional subset usually localized within the intestine, are recruited to the liver and spleen at the late stage of malaria infection, and contribute to protection against malaria infection via a multifunctional approach in apoptosis inhibitor-deficient mice. |