| First Author | Caldwell HK | Year | 2009 |
| Journal | Physiol Behav | Volume | 97 |
| Issue | 1 | Pages | 131-4 |
| PubMed ID | 19419666 | Mgi Jnum | J:150596 |
| Mgi Id | MGI:3851055 | Doi | 10.1016/j.physbeh.2009.02.006 |
| Citation | Caldwell HK, et al. (2009) Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more 'wild' background. Physiol Behav 97(1):131-4 |
| abstractText | It has been previously reported that vasopressin 1b receptor knockout (Avpr1b(-/-)) mice have reduced levels of aggressive behavior compared to wildtype littermates. However, as the background of the mice was always a mixture of 129/SvJ and C57BL/6, we wanted to determine if the phenotype persisted when our laboratory line was crossed with a wild-derived sub-species of house mice. To this end, we crossed our Avpr1b(-/-) mice with Mus musculus castaneus, one of the few sub-species that will breed with laboratory strains. Subsequent F(2) offspring were tested in a resident-intruder behavioral test to assess aggressive behavior. We found that even on this more 'wild' background, Avpr1b(-/-) mice continued to demonstrate longer attack latencies and fewer attacks in a resident-intruder test than wildtype littermates. These findings are consistent with previous reports of reduced aggressive behavior in Avpr1b(-/-) mice and show that the deficit does persist on a different background strain. Further, these findings confirm the importance of the Avpr1b to normal displays of social forms of aggressive behavior. |
