| First Author | Han R | Year | 2012 |
| Journal | Genesis | Volume | 50 |
| Issue | 11 | Pages | 783-800 |
| PubMed ID | 22611050 | Mgi Jnum | J:189569 |
| Mgi Id | MGI:5446118 | Doi | 10.1002/dvg.22039 |
| Citation | Han R, et al. (2012) A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis 50(11):783-800 |
| abstractText | Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits. When Bmpr2/Acvr2a function is reduced in cutaneous epithelium, hair follicles undergo rapid cycles of hair generation and loss. Alopecia results from a failure to terminate hair development properly, as hair clubs never form, and follicular retraction is slowed. Hair regeneration is rapid due to premature activation of new hair-production programs. Hair shafts differentiate aberrantly due to impaired arrest of medullary-cell proliferation. When Bmpr2/Acvr2a function is reduced in melanocytes, gray hair develops, as melanosomes differentiate but fail to grow, resulting in organelle miniaturization. We conclude that Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division. genesis 1-18, 2012. (c) 2012 Wiley Periodicals, Inc. |
