|  Help  |  About  |  Contact Us

Protein Coding Gene : Madd MAP-kinase activating death domain

Primary Identifier  MGI:2444672 Organism  Mus musculus
Chromosome  2 NCBI Gene Number  228355
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 5.4.0)

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in axon cytoplasm. Is expressed in nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain).
PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth due to respiratory failure, are hyporesponsive to tactile stimuli, and exhibit defects in neurotransmitter release with impaired synaptic vesicle trafficking and depletion of synaptic vesicles at the neuromuscular junction. [provided by MGI curators]
  • synonyms:
  • MAP-kinase activating death domain,
  • 9630059K23Rik,
  • Madd,
  • Rab3 GEP,
  • mKIAA0358,
  • RIKEN cDNA 9630059K23 gene

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

5 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

345 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications