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Protein Coding Gene : Mmp14 matrix metallopeptidase 14 (membrane-inserted)

Primary Identifier  MGI:101900 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  17387
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables metalloendopeptidase activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell differentiation; and positive regulation of macrophage migration. Acts upstream of or within several processes, including chondrocyte proliferation; collagen catabolic process; and skeletal system morphogenesis. Predicted to be located in several cellular components, including cytosol; intermediate filament cytoskeleton; and macropinosome. Predicted to be active in extracellular space and plasma membrane. Predicted to colocalize with cytoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; musculoskeletal system; and sensory organ. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
PHENOTYPE: Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth,kidney, and submaxillary gland development. [provided by MGI curators]
  • synonyms:
  • matrix metallopeptidase 14 (membrane-inserted),
  • Mmp14,
  • MGD-MRK-18727,
  • small and bugged-eyed,
  • AI325305,
  • MT1-MMP,
  • expressed sequence AI325305,
  • MGI:3717409,
  • Membrane type 1-MMP,
  • sabe,
  • MGI:2145621

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For