| Primary Identifier | MGI:104659 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 13388 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including negative regulation of cell differentiation; nervous system development; and regionalization. Acts upstream of or within several processes, including inner ear development; negative regulation of cell differentiation; and regionalization. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1). PHENOTYPE: Homozygous null embryos do not survive and have mesodermal segments with no cranio-caudal polarity and no epithelial somites develop; caudal sclerotome halves do not condense, the pattern. Mice heterozygous for a knock-out or ENU allele exhibit abnormal metabolic and immunological phenotypes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
