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Publication : Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells.

First Author  Gröbner S Year  2007
Journal  Infect Immun Volume  75
Issue  1 Pages  512-7
PubMed ID  17074859 Mgi Jnum  J:116649
Mgi Id  MGI:3694616 Doi  10.1128/IAI.00756-06
Citation  Grobner S, et al. (2007) Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells. Infect Immun 75(1):512-7
abstractText  In an initial period (< or =4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.
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