| Primary Identifier | MGI:3054946 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(KRT10BMP6)VI632Mbl |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic mice on an FVB background appear normal at birth, but begin to show skin abnormalities at about 6 days of age. Inflammatory lesions develop by 2-3 weeks of age. The skin condition progressively worsens and is characterized by hair loss, flaky skin, and nail abnormalities. As the transgene inserted into the Y Chromosome, only males are affected. |
| molecularNote | The transgene contains the human bone morphogenic protein 6 (BMP6) gene under the control of the bovine keratin 10 promoter. |
