| First Author | Revert-Ros F | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 40 | Pages | 35030-43 |
| PubMed ID | 21832087 | Mgi Jnum | J:177789 |
| Mgi Id | MGI:5296279 | Doi | 10.1074/jbc.M111.249458 |
| Citation | Revert-Ros F, et al. (2011) Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). J Biol Chem 286(40):35030-43 |
| abstractText | Goodpasture antigen-binding protein-1 (GPBP-1) is an exportable non-conventional Ser/Thr kinase that regulates glomerular basement membrane collagen organization. Here we provide evidence that GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis. Myoblasts deficient in GPBP-1 display defective myofibril formation, whereas myofibrils assemble with enhanced efficiency in those overexpressing GPBP-1. We also show that GPBP-1 targets the previously unidentified GIP130 (GPBP-interacting protein of 130 kDa), which binds to myosin and promotes its myofibrillar assembly. This report reveals that GPBP-1 directs myofibril formation, an observation that expands its reported role in supramolecular organization of structural proteins to the intracellular compartment. |
