| First Author | Li YF | Year | 2016 |
| Journal | Immunology | Volume | 148 |
| Issue | 2 | Pages | 140-9 |
| PubMed ID | 26849109 | Mgi Jnum | J:246185 |
| Mgi Id | MGI:5924455 | Doi | 10.1111/imm.12592 |
| Citation | Li YF, et al. (2016) Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 148(2):140-9 |
| abstractText | MicroRNAs have been shown to play a role in B-cell differentiation and activation. Here, we found miR-182 to be highly induced in activated B cells. However, mice lacking miR-182 have normal B-cell and T-cell development. Interestingly, mutant mice exhibited a defective antibody response at early time-points in the immunization regimen when challenged with a T-cell-dependent antigen. Germinal centres were formed but the generation of extrafollicular plasma cells was defective in the spleens of immunized miR-182-deficient mice. Mutant mice were also not able to respond to a T-cell-independent type 2 antigen, which typically elicited an extrafollicular B-cell response. Taken together, the data indicated that miR-182 plays a critical role in driving extrafollicular B-cell antibody responses. |
