| First Author | Doisne JM | Year | 2011 |
| Journal | J Immunol | Volume | 186 |
| Issue | 2 | Pages | 662-6 |
| PubMed ID | 21169541 | Mgi Jnum | J:168762 |
| Mgi Id | MGI:4938208 | Doi | 10.4049/jimmunol.1002725 |
| Citation | Doisne JM, et al. (2011) Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol 186(2):662-6 |
| abstractText | We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor gammat(+) NK1.1(-) invariant NKT (iNKT) cells produce IL-17A independently of IL-6. In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies on IL-23-mediated upregulation of IL-23R and IL-1R1 expression. We further show that IL-1 and IL-23 produced by pathogen-associated molecular pattern-stimulated dendritic cells induce this response from NK1.1(-) iNKT cells in vitro, involving mainly TLR2/4-signaling pathways. Finally, we found that IL-17A production by these cells occurs very early and transiently in vivo in response to heat-killed bacteria. Overall, our study indicates that peripheral lymph node NK1.1(-) iNKT cells could be a source of innate Th17-related cytokines during bacterial infections and supports the hypothesis that they are able to provide an efficient first line of defense against bacterial invasion. |
