| First Author | Yuan Y | Year | 2013 |
| Journal | Neurosci Lett | Volume | 536 |
| Pages | 10-3 | PubMed ID | 23328440 |
| Mgi Jnum | J:197751 | Mgi Id | MGI:5494497 |
| Doi | 10.1016/j.neulet.2013.01.002 | Citation | Yuan Y, et al. (2013) Mef2 promotes spine elimination in absence of delta-catenin. Neurosci Lett 536:10-3 |
| abstractText | delta-Catenin is a component of the cadherin-catenin cell adhesion complex and its loss has been implicated in the mental retardation associated with the Cri du chat syndrome. We have previously demonstrated that loss of delta-catenin in a murine model during development results in excessive spine and synaptic density and function. In order to examine the role of potential molecules that might cooperate with delta-catenin to regulate spine density, we focused on Mef2. Our data demonstrate that while loss of delta-catenin does not alter the expression levels of endogenous Mef2, expression of Mef2 in neurons that are knocked down for delta-catenin promotes spine elimination. These results establish a molecular mechanism by which excessive spines in the absence of delta-catenin may be eliminated and may point toward pharmacological therapy for the Cri du chat syndrome. |
