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Protein Coding Gene : Dgcr8 DGCR8, microprocessor complex subunit
Primary Identifier  MGI:2151114 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  94223
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables primary miRNA binding activity. Acts upstream of or within regulation of stem cell proliferation. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including brain; cardiovascular system; early embryo; facial prominence; and hemolymphoid system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit).
PHENOTYPE: Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homozygous mice are embryonic lethal. [provided by MGI curators]
  • synonyms:
  • DNA segment, Chr 16, Wisconsin 2,
  • Dgcr8,
  • Gy1,
  • D16Wis2,
  • N41,
  • DNA segment, Chr 16, human D22S788, expressed,
  • DNA segment, Chr 16, human D22S1742E, expressed,
  • Vo59c07,
  • MGI:1202891,
  • D16H22S1742E,
  • MGI:1927907,
  • MGI:892900,
  • MGI:1098823,
  • DGCR8, microprocessor complex subunit,
  • D16H22S788E,
  • DiGeorge syndrome critical region gene 8,
  • Vo59c07 gene
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