Primary Identifier | MGI:2664159 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Guca1a |
Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Guca1a and Guca1b, which are arranged tail-to-tail, were disrupted by the insertion of a single neo cassette. The deleted region encompassed exons 2 through 4 of Guca1a and exons 3 and 4 of Guca1b. Immunostaining and Western blot analysis of homozygous mutant retinal tissue indicated an absence of proteins. |