Primary Identifier | MGI:5751734 | Allele Type | Targeted |
Gene | Psen1 | Transmission | Germline |
Strain of Origin | (C57BL/6 x 129)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | An C410Y (1229G to A) mutation was inserted in exon 11 and a floxed neo cassette was inserted in intron 11 via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation in exon 11 severely impairs gamma-secretase activity. |