| First Author | Wu A | Year | 2003 |
| Journal | J Cell Physiol | Volume | 195 |
| Issue | 3 | Pages | 453-60 |
| PubMed ID | 12704655 | Mgi Jnum | J:83367 |
| Mgi Id | MGI:2661316 | Doi | 10.1002/jcp.10261 |
| Citation | Wu A, et al. (2003) Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts. J Cell Physiol 195(3):453-60 |
| abstractText | Translocation of the insulin receptor substrate-1 (IRS-1) to the nuclei has been reported to occur in cells stimulated by insulin-like growth factor-1 (IGF-I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS-1 in mouse embryo fibroblasts (MEF), that do not express the type 1 insulin-like growth factor receptor (IGF-IR). Only the A isoform of the insulin receptor (IR) can induce IRS-1 nuclear translocation, which is significant when the receptor is over-expressed. At physiological receptor levels, translocation occurs only in a fraction of cells, and only at high concentrations of ligand. |
