| First Author | Robertson J | Year | 2005 |
| Journal | Neurobiol Aging | Volume | 26 |
| Issue | 5 | Pages | 637-43 |
| PubMed ID | 15708438 | Mgi Jnum | J:101973 |
| Mgi Id | MGI:3605977 | Doi | 10.1016/j.neurobiolaging.2004.06.003 |
| Citation | Robertson J, et al. (2005) apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiol Aging 26(5):637-43 |
| abstractText | Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety. |
