Primary Identifier | MGI:2154239 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 140570 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators] |