| First Author | Pearse RV 2nd | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 14 | Pages | 7555-60 |
| PubMed ID | 9207130 | Mgi Jnum | J:41753 |
| Mgi Id | MGI:894437 | Doi | 10.1073/pnas.94.14.7555 |
| Citation | Pearse RV 2nd, et al. (1997) Reduced fertility in mice deficient for the POU protein sperm-1. Proc Natl Acad Sci U S A 94(14):7555-60 |
| abstractText | Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell. |
