| First Author | Dubois SP | Year | 2005 |
| Journal | Proc Natl Acad Sci U S A | Volume | 102 |
| Issue | 24 | Pages | 8662-7 |
| PubMed ID | 15932944 | Mgi Jnum | J:99726 |
| Mgi Id | MGI:3583508 | Doi | 10.1073/pnas.0503360102 |
| Citation | Dubois SP, et al. (2005) Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci U S A 102(24):8662-7 |
| abstractText | The survival of CD8+/CD44(hi) memory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were induced on dendritic cells (DCs) by a combination of IFN-gamma and NF-kappaB relA inducers. IL-15 conferred in an autocrine loop resistance to apoptosis that accompanied the maturation process in DCs in vitro. As an apparent result in vivo, mice deficient in IL-15 or its receptor harbor few DCs. Injecting DCs into IL-15-/- mice was associated with the appearance of CD8+/CD44(hi) T cells that depended on IL-15 expression but also correlated with the longevity of the DCs. These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44(hi) memory phenotype T cells. |
