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Protein Coding Gene : Top3b topoisomerase (DNA) III beta
Primary Identifier  MGI:1333803 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  21976
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within chromosome segregation. Located in condensed chromosome. Is expressed in liver. Orthologous to human TOP3B (DNA topoisomerase III beta).
PHENOTYPE: Homozygous null mice develop to maturity but die prematurely showing enlargement of lymphatic organs and glomerulonephritis. Intercrossing of mutant mice progressively results in infertility that is correlated to increased aneuploidy in germ cells. [provided by MGI curators]
  • synonyms:
  • topoisomerase (DNA) III beta,
  • Topo III beta,
  • Top3b
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