| First Author | Torres RM | Year | 1996 |
| Journal | Science | Volume | 272 |
| Issue | 5269 | Pages | 1804-8 |
| PubMed ID | 8650582 | Mgi Jnum | J:80885 |
| Mgi Id | MGI:2447422 | Doi | 10.1126/science.272.5269.1804 |
| Citation | Torres RM, et al. (1996) Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272(5269):1804-8 |
| abstractText | The immunoglobulin alpha (Ig-alpha)-Ig-beta heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-alpha cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-alpha signaling in antibody responses such that a signaling-competent Ig-alpha appears to be critical for the response to T-independent, but not T-dependent, antigens. |
