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Allele : Gt(ROSA)26Sor<tm5(PTK2*Y397E*K454R)Khd> gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Kairbaan M Hodivala-Dilke
Primary Identifier  MGI:5704298 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S6/SvEvTac or C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  A construct consisting of a floxed neo-stop cassette, chicken PTK2 cDNA with two mutations (Y397E and K454R) a Myc tag and an IRES-EGFP cassette was inserted into the locus. No GFP expression was detected. The mutations disrupt the kinase domain and mimic a constitutively phosphorylated form.
  • mutations:
  • Insertion
  • synonyms:
  • R26FAK<KI>,
  • R26FAK<KI>,
  • 397E/KD,
  • 397E/KD
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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