| First Author | Arce I | Year | 2004 |
| Journal | Eur J Immunol | Volume | 34 |
| Issue | 1 | Pages | 210-20 |
| PubMed ID | 14971047 | Mgi Jnum | J:87625 |
| Mgi Id | MGI:3027348 | Doi | 10.1002/eji.200324230 |
| Citation | Arce I, et al. (2004) The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Eur J Immunol 34(1):210-20 |
| abstractText | Cell surface lectin receptors play important roles in the function of macrophages. Herein, we have identified and characterized the human orthologue of the mouse Mcl/Clecsf8.Human CLECSF8 codes for a type II membrane glycoprotein of 215 amino acids that belongs to the human calcium-dependent lectin family (C-type lectin). The cytoplasmic tail of CLECSF8 lacks consensus signaling motifs and its extracellular region shows a single carbohydrate recognition domain (CRD). The CLECSF8 gene has been localized on the telomeric region of the NK gene complex on chromosome 12p13 close to MINCLE. CLECSF8 mRNA shows a monocyte/macrophage expression pattern. Biochemical analysis of CLECSF8 on transiently transfected cells showed a glycoprotein of 30 kDa. Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor.See accompanying commentary http://dx.doi.org/10.1002/eji.200324641 |
