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Protein Coding Gene : Sim2 single-minded family bHLH transcription factor 2

Primary Identifier  MGI:98307 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  20465
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables DNA binding activity and protein heterodimerization activity. Acts upstream of or within embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; future brain; genitourinary system; limb; and musculoskeletal system. Orthologous to human SIM2 (SIM bHLH transcription factor 2).
PHENOTYPE: Homozygous mutation of this gene results in postnatal lethality, cleft palate, malformed pterygoid processes, and aerophagia. [provided by MGI curators]
  • synonyms:
  • Sim2,
  • single-minded family bHLH transcription factor 2,
  • bHLHe15,
  • MGD-MRK-14415

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

11 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For