| Primary Identifier | MGI:96969 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 17295 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables hepatocyte growth factor receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including hepatocyte growth factor receptor signaling pathway; regulation of cytokine production; and striated muscle cell differentiation. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). PHENOTYPE: Homozygous null mutants exhibit impaired embryonic development resulting in death. Abnormalities observed in various mutant lines include muscle agenesis due to impaired migration of myogenic precursors, defects of motor axon migration, and placental and liver defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
